Assay Detail
Functional
CHEMBL1655341
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Follicle-stimulating hormone receptor (CHEMBL2024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Selective LH Receptor Agonists by Heterodimerization with a FSH Receptor Antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.65 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651721 | — | — | 1 | 6.90 |
| CHEMBL1651828 | — | — | 1 | 6.40 |
| CHEMBL1651722 | — | — | 1 | - |
| CHEMBL1651723 | — | — | 1 | - |
| CHEMBL1651823 | — | — | 1 | - |
| CHEMBL1651824 | — | — | 1 | - |
| CHEMBL1651825 | — | — | 1 | - |
| CHEMBL1651826 | — | — | 1 | - |
| CHEMBL1651827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651721 | — | EC50 | = | 126.0 | nM | 6.90 |
| CHEMBL1651828 | — | EC50 | = | 397.0 | nM | 6.40 |
| CHEMBL1651722 | — | EC50 | - | — | - | |
| CHEMBL1651723 | — | EC50 | - | — | - | |
| CHEMBL1651823 | — | EC50 | - | — | - | |
| CHEMBL1651824 | — | EC50 | - | — | - | |
| CHEMBL1651825 | — | EC50 | - | — | - | |
| CHEMBL1651826 | — | EC50 | - | — | - | |
| CHEMBL1651827 | — | EC50 | - | — | - |