Assay Detail
Functional
CHEMBL1655339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lutropin-choriogonadotropic hormone receptor (CHEMBL1854) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Selective LH Receptor Agonists by Heterodimerization with a FSH Receptor Antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.60 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651721 | — | — | 1 | 9.00 |
| CHEMBL1651828 | — | — | 1 | 8.30 |
| CHEMBL1651723 | — | — | 1 | 8.00 |
| CHEMBL1651829 | — | — | 1 | 7.62 |
| CHEMBL1651823 | — | — | 1 | 7.57 |
| CHEMBL1651831 | — | — | 1 | 7.41 |
| CHEMBL1651824 | — | — | 1 | 7.37 |
| CHEMBL1651826 | — | — | 1 | 7.26 |
| CHEMBL1651822 | — | — | 1 | 7.24 |
| CHEMBL1651825 | — | — | 1 | 7.21 |
| CHEMBL1651821 | — | — | 1 | 7.12 |
| CHEMBL1651830 | — | — | 1 | 7.10 |
| CHEMBL1651722 | — | — | 1 | - |
| CHEMBL1651827 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651721 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1651828 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1651723 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1651829 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1651823 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1651831 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1651824 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1651826 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1651822 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1651825 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1651821 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1651830 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1651722 | — | EC50 | - | — | - | |
| CHEMBL1651827 | — | EC50 | - | — | - |