Glutamate NMDA receptor; GRIN1/GRIN2A · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q05586. Use UniProt Q05586 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q05586 as the stable identity anchor, then attach disease evidence before program review.
Glutamate receptor ionotropic, NMDA 1
Review this target as Glutamate NMDA receptor; GRIN1/GRIN2A, mapped to UniProt Q05586. ChEMBL maps the protein component as Glutamate receptor ionotropic, NMDA 1. Sequence length is 938 aa.
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This review treats Glutamate NMDA receptor; GRIN1/GRIN2A as ChEMBL target CHEMBL1907604, mapped to UniProt Q05586. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glutamate NMDA receptor; GRIN1/GRIN2A |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q05586 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamate receptor ionotropic, NMDA 1 |
| UniProt Accession | Q05586 |
| Component Type | Protein |
| Sequence Length | 938 aa |
Glutamate receptor ionotropic, NMDA 1
Review this target as Glutamate NMDA receptor; GRIN1/GRIN2A, mapped to UniProt Q05586. ChEMBL maps the protein component as Glutamate receptor ionotropic, NMDA 1. Sequence length is 938 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL12513 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL807 | 9.02 | IC50 | 0.95 | Approved |
| CHEMBL274422 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL2398522 | 8.38 | IC50 | 4.2 | Preclinical |
| CHEMBL536107 | 8.38 | IC50 | 4.2 | Preclinical |
| CHEMBL1165411 | 8.01 | IC50 | 9.7 | Clinical |
| CHEMBL55568 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL395091 | 7.94 | IC50 | 11.4 | Approved |
| CHEMBL275528 | 7.93 | IC50 | 11.8 | Clinical |
| CHEMBL3800556 | 7.75 | EC50 | 17.7 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 64 | 200 | 5.9 |
| protein complex format | 13 | 66 | 6.2 |
| assay format | 1 | 0 | — |
| tissue-based format | 1 | 1 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 25 | 6.4 |