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Compound Detail

CHEMBL55568

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c1ccc(C(CNCCCCCCNCCCCCCCCNCCCCCCNCC(c2ccccc2)c2ccccc2)c2ccccc2)cc1

Basic Information

ChEMBL ID CHEMBL55568
Phase Preclinical
Structure Type MOL
InChI Key NRCHURHJYYUUJQ-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

703.1
MW (Da)
10.47
ALogP
4
HBA
4
HBD
48.1
PSA (Ų)
0.04
QED
2
Ro5 Violations
31
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C48H70N4
MW 703.12
Aromatic Rings 4
Heavy Atoms 52
NP-Likeness -0.07

Activity Summary

IC50 5 meas. best 7.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Glutamate NMDA receptor; GRIN1/GRIN2A
CHEMBL1907604
IC50 7.96 7.96 11.0 1
Unchecked
CHEMBL612545
IC50 6.31 6.31 489.8 1
HeLa
CHEMBL399
IC50 4.75 4.75 18000.0 1
ADMET
CHEMBL612558
IC50 4.22 4.22 60000.0 1
Thymocyte
CHEMBL613302
IC50 4.09 4.09 82000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23887056 10.1016/j.ejmech.2013.06.044 HeLa 2
11960498 10.1021/jm011067f Unchecked 1
11960498 10.1021/jm011067f Muscarinic acetylcholine receptor M2 1
11960498 10.1021/jm011067f Muscarinic acetylcholine receptor M3 1
23692871 10.1016/j.bmcl.2013.04.063 Mus musculus 1
23692871 10.1016/j.bmcl.2013.04.063 Glutamate NMDA receptor; GRIN1/GRIN2A 1
23887056 10.1016/j.ejmech.2013.06.044 Thymocyte 1
23887056 10.1016/j.ejmech.2013.06.044 ADMET 1

Data from ChEMBL 36 via Core Engine