Assay Detail
Functional
CHEMBL753101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of carbachol action on nAChR of isolated frog rectus abdominus.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | frog |
| Tissue | Rectus abdominis muscle |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Expert |
Publication
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.11 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55343 | — | — | 1 | 7.11 |
| CHEMBL55587 | — | — | 1 | 7.02 |
| CHEMBL292391 | — | — | 1 | 6.68 |
| CHEMBL55463 | — | — | 1 | 6.66 |
| CHEMBL51850 | — | — | 1 | 6.44 |
| CHEMBL54725 | — | — | 1 | 6.43 |
| CHEMBL56043 | — | — | 1 | 6.42 |
| CHEMBL54113 | — | — | 1 | 6.39 |
| CHEMBL55568 | — | — | 1 | 6.31 |
| CHEMBL300930 | — | — | 1 | 6.30 |
| CHEMBL55549 | — | — | 1 | 6.30 |
| CHEMBL293128 | — | — | 1 | 6.27 |
| CHEMBL52619 | — | — | 1 | 6.21 |
| CHEMBL54680 | — | — | 1 | 6.17 |
| CHEMBL54469 | METHYLTRIPHENYLPHOSPHONIUM BROMIDE | — | 1 | 6.05 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 5.93 |
| CHEMBL294613 | — | — | 1 | 5.88 |
| CHEMBL300964 | — | — | 1 | 5.80 |
| CHEMBL27739 | — | — | 1 | 5.62 |
| CHEMBL55765 | — | — | 1 | 5.48 |
| CHEMBL55333 | — | — | 1 | 5.36 |
| CHEMBL294865 | — | — | 1 | 5.14 |
| CHEMBL55975 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55343 | — | IC50 | = | 77.62 | nM | 7.11 |
| CHEMBL55587 | — | IC50 | = | 95.5 | nM | 7.02 |
| CHEMBL292391 | — | IC50 | = | 208.93 | nM | 6.68 |
| CHEMBL55463 | — | IC50 | = | 218.78 | nM | 6.66 |
| CHEMBL51850 | — | IC50 | = | 363.08 | nM | 6.44 |
| CHEMBL54725 | — | IC50 | = | 371.54 | nM | 6.43 |
| CHEMBL56043 | — | IC50 | = | 380.19 | nM | 6.42 |
| CHEMBL54113 | — | IC50 | = | 407.38 | nM | 6.39 |
| CHEMBL55568 | — | IC50 | = | 489.78 | nM | 6.31 |
| CHEMBL300930 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL55549 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL293128 | — | IC50 | = | 537.03 | nM | 6.27 |
| CHEMBL52619 | — | IC50 | = | 616.6 | nM | 6.21 |
| CHEMBL54680 | — | IC50 | = | 676.08 | nM | 6.17 |
| CHEMBL54469 | METHYLTRIPHENYLPHOSPHONIUM BROMIDE | IC50 | = | 891.25 | nM | 6.05 |
| CHEMBL27673 | METHOCTRAMINE | IC50 | = | 1174.9 | nM | 5.93 |
| CHEMBL294613 | — | IC50 | = | 1318.26 | nM | 5.88 |
| CHEMBL300964 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL27739 | — | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL55765 | — | IC50 | = | 3311.31 | nM | 5.48 |
| CHEMBL55333 | — | IC50 | = | 4365.16 | nM | 5.36 |
| CHEMBL294865 | — | IC50 | = | 7244.36 | nM | 5.14 |
| CHEMBL55975 | — | IC50 | = | 23988.33 | nM | 4.62 |