Serine/threonine-protein kinase PknB · SINGLE PROTEIN · Mycobacterium tuberculosis
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As of 2026-09-13Protein identity stays anchored to UniProt P9WI81. Use UniProt P9WI81 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P9WI81 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase PknB
Review this target as Serine/threonine-protein kinase PknB, mapped to UniProt P9WI81. Sequence length is 626 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase PknB as ChEMBL target CHEMBL1908385, mapped to UniProt P9WI81. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase PknB |
| Target Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
| UniProt | P9WI81 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase PknB |
| UniProt Accession | P9WI81 |
| Component Type | Protein |
| Sequence Length | 626 aa |
Serine/threonine-protein kinase PknB
Review this target as Serine/threonine-protein kinase PknB, mapped to UniProt P9WI81. Sequence length is 626 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL494089 | 8.49 | Kd | 3.2 | Preclinical |
| CHEMBL502835 | 8.44 | Kd | 3.6 | Approved |
| CHEMBL4173915 | 8.4 | Ki | 4.0 | Preclinical |
| CHEMBL4170479 | 8.4 | Ki | 4.0 | Preclinical |
| CHEMBL4177229 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL4170653 | 8.22 | Ki | 6.0 | Preclinical |
| CHEMBL4177445 | 7.89 | Ki | 13.0 | Preclinical |
| CHEMBL4165949 | 7.82 | Ki | 15.0 | Preclinical |
| CHEMBL4172982 | 7.77 | Ki | 17.0 | Preclinical |
| CHEMBL5282194 | 7.72 | Kd | 19.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 19 | 35 | 5.8 |
| assay format | 17 | 42 | 6.8 |
| cell-based format | 3 | 49 | 6.5 |