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Evidence Snapshot

Serine/threonine-protein kinase PknB

CHEMBL1908385 SINGLE PROTEIN Mycobacterium tuberculosis
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:04Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1908385
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase PknB as ChEMBL target CHEMBL1908385, mapped to UniProt P9WI81. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase PknB
SINGLE PROTEIN · Mycobacterium tuberculosis
As of 2026-09-14
ChEMBL target ID
CHEMBL1908385
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P9WI81
Serine/threonine-protein kinase PknB
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Serine/threonine-protein kinase PknB matters

As of 2026-09-14

Serine/threonine-protein kinase PknB is reviewed as Serine/threonine-protein kinase PknB (UniProt P9WI81); the current evidence base includes 6 approved drugs, 321 compounds, and 39 assays, with lead potency reaching pChEMBL 8.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 6 approved drugs, 321 compounds, and 39 assays for this target. The dominant activity type is KD. CHEMBL494089 is the current potency anchor at pChEMBL 8.5.

Use CHEMBL494089 as the tractability anchor when discussing potency (pChEMBL 8.5).

Activity source · ChEMBL 36 via Core Engine
6 approved pChEMBL 8.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Serine/threonine-protein kinase PknB matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P9WI81, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

321
Total Compounds
39
Total Assays
6
Approved Drugs
IC50: 55.0, KI: 70.0, KD: 96.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL494089
 8.5 Kd —
No preferred name
CHEMBL502835
 8.4 Kd Approved
No preferred name
CHEMBL4170479
 8.4 Ki —
No preferred name
CHEMBL4173915
 8.4 Ki —
No preferred name
CHEMBL4177229
 8.3 Ki —

Approved Drugs

Structure Compound First Approval
FEDRATINIB
CHEMBL1287853
 2019
NINTEDANIB
CHEMBL502835
 2014
SUNITINIB
CHEMBL535
 2006
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:04Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1908385