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Target Snapshot

CHEMBL1914263 Target Snapshot

Sphingosine 1-phosphate receptor 1 · SINGLE PROTEIN · Rattus norvegicus

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14Compounds
14Assays
1Approved Drugs
19.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P48303. Use UniProt P48303 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P48303 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sphingosine 1-phosphate receptor 1 as ChEMBL target CHEMBL1914263, mapped to UniProt P48303. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sphingosine 1-phosphate receptor 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL1914263
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P48303
Sphingosine 1-phosphate receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sphingosine 1-phosphate receptor 1 is the right protein anchor across sources, using UniProt P48303 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameSphingosine 1-phosphate receptor 1
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP48303
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSphingosine 1-phosphate receptor 1
UniProt AccessionP48303
Component TypeProtein
Sequence Length383 aa

Sphingosine 1-phosphate receptor 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Sphingosine 1-phosphate receptor 1, mapped to UniProt P48303. Sequence length is 383 aa.

Mapped IDP48303
Review nameSphingosine 1-phosphate receptor 1
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

KI1.0
EC5018.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4093489 10.54 EC50 0.0286 Preclinical
CHEMBL3403619 10.4 EC50 0.04 Preclinical
CHEMBL3359523 10.3 EC50 0.05 Preclinical
CHEMBL3359522 10.14 EC50 0.072 Preclinical
CHEMBL2048293 10.0 EC50 0.1 Preclinical
CHEMBL366208 9.54 EC50 0.29 Preclinical
CHEMBL3959509 9.51 EC50 0.31 Preclinical
CHEMBL3358920 9.49 EC50 0.32 Approved
CHEMBL4093489 9.11 Ki 0.772 Preclinical
CHEMBL1916399 9.0 EC50 1.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
2
8.0
6
8.5
3
9.0
3
9.5
pChEMBL
Approved Drugs

Approved Drugs

ETRASIMOD
CHEMBL3358920
Approved 2023
Properties Compare Identifier
Assay Landscape

Assay Landscape

14
Total Assays
13
Tested Compounds
2
Assay Types
Functional — 12 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 6 6 9.6
cell-based format 4 6 8.9
single protein format 2 1 10.4
Binding — 2 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell membrane format 1 1 9.5
single protein format 1 1 9.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine