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Evidence Snapshot

Sphingosine 1-phosphate receptor 1

CHEMBL1914263 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:45:07Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1914263
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sphingosine 1-phosphate receptor 1 as ChEMBL target CHEMBL1914263, mapped to UniProt P48303. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sphingosine 1-phosphate receptor 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL1914263
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P48303
Sphingosine 1-phosphate receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Sphingosine 1-phosphate receptor 1 matters

As of 2026-09-13

Sphingosine 1-phosphate receptor 1 is reviewed as Sphingosine 1-phosphate receptor 1 (UniProt P48303); the current evidence base includes 1 approved drug, 14 compounds, and 14 assays, with lead potency reaching pChEMBL 10.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 1 approved drug, 14 compounds, and 14 assays for this target. The dominant activity type is EC50. CHEMBL4093489 is the current potency anchor at pChEMBL 10.5.

Use CHEMBL4093489 as the tractability anchor when discussing potency (pChEMBL 10.5).

Activity source · ChEMBL 36 via Core Engine
1 approved pChEMBL 10.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Sphingosine 1-phosphate receptor 1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P48303, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

14
Total Compounds
14
Total Assays
1
Approved Drugs
KI: 1.0, EC50: 18.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4093489
 10.5 EC50 —
No preferred name
CHEMBL3403619
 10.4 EC50 —
No preferred name
CHEMBL3359523
 10.3 EC50 —
No preferred name
CHEMBL3359522
 10.1 EC50 —
No preferred name
CHEMBL2048293
 10.0 EC50 —

Approved Drugs

Structure Compound First Approval
ETRASIMOD
CHEMBL3358920
 2023
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T20:45:07Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1914263