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Target Snapshot

CHEMBL1938219 Target Snapshot

Neuropeptides B/W receptor type 1 · SINGLE PROTEIN · Mus musculus

41Compounds
2Assays
0Approved Drugs
82.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P49681. Use UniProt P49681 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P49681 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neuropeptides B/W receptor type 1 as ChEMBL target CHEMBL1938219, mapped to UniProt P49681. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neuropeptides B/W receptor type 1
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL1938219
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P49681
Neuropeptides B/W receptor type 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neuropeptides B/W receptor type 1 is the right protein anchor across sources, using UniProt P49681 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeuropeptides B/W receptor type 1
UniProt AccessionP49681
Component TypeProtein
Sequence Length329 aa

Neuropeptides B/W receptor type 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Neuropeptides B/W receptor type 1, mapped to UniProt P49681. Sequence length is 329 aa.

Mapped IDP49681
Review nameNeuropeptides B/W receptor type 1
OrganismMus musculus
Assay Mix

Activity Type Distribution

IC5082.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1938418 9.74 IC50 0.18 Preclinical
CHEMBL1940544 9.7 IC50 0.2 Preclinical
CHEMBL1940540 9.48 IC50 0.33 Preclinical
CHEMBL1940545 9.38 IC50 0.42 Preclinical
CHEMBL1940543 9.37 IC50 0.43 Preclinical
CHEMBL1940537 9.16 IC50 0.69 Preclinical
CHEMBL1940539 8.96 IC50 1.1 Preclinical
CHEMBL1940536 8.72 IC50 1.9 Preclinical
CHEMBL1940541 8.66 IC50 2.2 Preclinical
CHEMBL1940538 8.62 IC50 2.4 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
9
5.5
7
6.0
10
6.5
7
7.0
13
7.5
7
8.0
10
8.5
6
9.0
2
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
40
Tested Compounds
2
Assay Types
Binding — 1 assays, 37 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 37 7.8
Functional — 1 assays, 40 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 40 6.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine