Runt-related transcription factor 1/Core-binding factor subunit beta · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q01196. Use UniProt Q01196 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q01196 as the stable identity anchor, then attach disease evidence before program review.
Runt-related transcription factor 1
Review this target as Runt-related transcription factor 1/Core-binding factor subunit beta, mapped to UniProt Q01196. ChEMBL maps the protein component as Runt-related transcription factor 1. Sequence length is 453 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Runt-related transcription factor 1/Core-binding factor subunit beta as ChEMBL target CHEMBL2093862, mapped to UniProt Q01196. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Runt-related transcription factor 1/Core-binding factor subunit beta is the right protein anchor across sources, using UniProt Q01196 as the stable mapping.
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| Preferred Name | Runt-related transcription factor 1/Core-binding factor subunit beta |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | Q01196 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Runt-related transcription factor 1 |
| UniProt Accession | Q01196 |
| Component Type | Protein |
| Sequence Length | 453 aa |
Runt-related transcription factor 1
Review this target as Runt-related transcription factor 1/Core-binding factor subunit beta, mapped to UniProt Q01196. ChEMBL maps the protein component as Runt-related transcription factor 1. Sequence length is 453 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1487114 | 6.59 | IC50 | 257.0 | Preclinical |
| CHEMBL1548014 | 6.47 | IC50 | 340.0 | Preclinical |
| CHEMBL1492213 | 6.43 | IC50 | 372.0 | Preclinical |
| CHEMBL1555914 | 6.41 | IC50 | 393.0 | Preclinical |
| CHEMBL1998294 | 6.37 | IC50 | 429.0 | Preclinical |
| CHEMBL1360981 | 6.32 | IC50 | 475.0 | Preclinical |
| CHEMBL1299795 | 6.2 | IC50 | 629.0 | Preclinical |
| CHEMBL1331901 | 6.19 | IC50 | 643.0 | Preclinical |
| CHEMBL1372231 | 6.15 | IC50 | 713.43 | Preclinical |
| CHEMBL1486938 | 6.06 | IC50 | 865.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 5 | 74 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 0 | — |