Melatonin receptor · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-15Melatonin receptor shows approved-linked disease relevance led by insomnia. 5 more disease programs remain visible in the same review block. 4 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P48039. Start with insomnia, then reuse UniProt P48039 as the stable protein anchor across project notes and exports.
Start with insomnia, then reuse UniProt P48039 as the stable protein anchor across project notes and exports.
Melatonin receptor shows approved-linked disease relevance led by insomnia. 5 more disease programs remain visible in the same review block. 4 linked drugs remain visible in the same block.
Start review with insomnia because it currently carries approved-linked support. Linked drugs include MELATONIN, PIROMELATINE, RAMELTEON, TASIMELTEON. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMelatonin receptor type 1A
Review this target as Melatonin receptor, mapped to UniProt P48039. ChEMBL maps the protein component as Melatonin receptor type 1A. Sequence length is 350 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Melatonin receptor as ChEMBL target CHEMBL2094268, mapped to UniProt P48039. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Melatonin receptor is the right protein anchor across sources, using UniProt P48039 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why insomnia is currently framed as approved-linked support. It currently carries 4 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Melatonin receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P48039 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Melatonin receptor type 1A |
| UniProt Accession | P48039 |
| Component Type | Protein |
| Sequence Length | 350 aa |
Melatonin receptor type 1A
Review this target as Melatonin receptor, mapped to UniProt P48039. ChEMBL maps the protein component as Melatonin receptor type 1A. Sequence length is 350 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Melatonin receptor shows approved-linked disease relevance led by insomnia. 5 more disease programs remain visible in the same review block.
Start review with insomnia because it currently carries approved-linked support. Linked drugs include MELATONIN, PIROMELATINE, RAMELTEON, TASIMELTEON. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL421013 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL134874 | 10.91 | Ki | 0.0123 | Preclinical |
| CHEMBL1218 | 10.86 | Ki | 0.0138 | Approved |
| CHEMBL433237 | 10.85 | Ki | 0.014 | Preclinical |
| CHEMBL64664 | 10.85 | Ki | 0.014 | Preclinical |
| CHEMBL320267 | 10.82 | IC50 | 0.0153 | Preclinical |
| CHEMBL15060 | 10.77 | Ki | 0.017 | Preclinical |
| CHEMBL45 | 10.77 | IC50 | 0.017 | Approved |
| CHEMBL134330 | 10.76 | Ki | 0.0174 | Preclinical |
| CHEMBL289233 | 10.68 | Ki | 0.021 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 34 | 60 | 7.7 |
| assay format | 9 | 46 | 7.7 |
| cell-based format | 4 | 53 | 8.9 |
| organism-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 19 | 25 | 8.2 |
| organism-based format | 5 | 0 | — |