Melatonin receptor · PROTEIN FAMILY · Gallus gallus
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As of 2026-09-13Protein identity stays anchored to UniProt P49288. Use UniProt P49288 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P49288 as the stable identity anchor, then attach disease evidence before program review.
Melatonin receptor type 1C
Review this target as Melatonin receptor, mapped to UniProt P49288. ChEMBL maps the protein component as Melatonin receptor type 1C. Sequence length is 346 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Melatonin receptor as ChEMBL target CHEMBL2095154, mapped to UniProt P49288. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Melatonin receptor is the right protein anchor across sources, using UniProt P49288 as the stable mapping.
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| Preferred Name | Melatonin receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Gallus gallus |
| UniProt | P49288 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Melatonin receptor type 1C |
| UniProt Accession | P49288 |
| Component Type | Protein |
| Sequence Length | 346 aa |
Melatonin receptor type 1C
Review this target as Melatonin receptor, mapped to UniProt P49288. ChEMBL maps the protein component as Melatonin receptor type 1C. Sequence length is 346 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL336054 | 10.96 | Ki | 0.011 | Preclinical |
| CHEMBL417988 | 10.72 | Ki | 0.019 | Preclinical |
| CHEMBL131252 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL290493 | 10.53 | Ki | 0.02951 | Preclinical |
| CHEMBL289233 | 10.49 | Ki | 0.03236 | Preclinical |
| CHEMBL340832 | 10.47 | Ki | 0.034 | Preclinical |
| CHEMBL428882 | 10.43 | EC50 | 0.037 | Preclinical |
| CHEMBL132802 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL14483 | 10.33 | Ki | 0.0466 | Preclinical |
| CHEMBL304203 | 10.3 | Ki | 0.05 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 13 | 161 | 7.7 |
| cell membrane format | 7 | 138 | 7.2 |
| protein format | 4 | 1 | 7.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 7 | 8.7 |