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Target Snapshot

CHEMBL2111391 Target Snapshot

Fibroblast growth factor receptor · PROTEIN FAMILY · Mus musculus

37Compounds
5Assays
0Approved Drugs
37.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P21803. Use UniProt P21803 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P21803 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Fibroblast growth factor receptor as ChEMBL target CHEMBL2111391, mapped to UniProt P21803. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Fibroblast growth factor receptor
PROTEIN FAMILY · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL2111391
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P21803
Fibroblast growth factor receptor 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Fibroblast growth factor receptor is the right protein anchor across sources, using UniProt P21803 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFibroblast growth factor receptor 2
UniProt AccessionP21803
Component TypeProtein
Sequence Length821 aa

Fibroblast growth factor receptor 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Fibroblast growth factor receptor, mapped to UniProt P21803. ChEMBL maps the protein component as Fibroblast growth factor receptor 2. Sequence length is 821 aa.

Mapped IDP21803
Review nameFibroblast growth factor receptor
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase I
Assay Mix

Activity Type Distribution

IC5037.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL112914 7.52 IC50 30.0 Preclinical
CHEMBL49120 7.37 IC50 43.0 Preclinical
CHEMBL136106 7.06 IC50 88.0 Preclinical
CHEMBL336409 6.7 IC50 200.0 Preclinical
CHEMBL136244 6.46 IC50 350.0 Preclinical
CHEMBL136280 6.43 IC50 370.0 Preclinical
CHEMBL337157 6.3 IC50 500.0 Preclinical
CHEMBL136775 6.29 IC50 510.0 Preclinical
CHEMBL139249 6.27 IC50 540.0 Preclinical
CHEMBL138319 6.24 IC50 580.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
11
5.5
8
6.0
1
6.5
2
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
23
Tested Compounds
2
Assay Types
Functional — 4 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 3 7 5.3
cell-based format 1 0
Binding — 1 assays, 23 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 1 23 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine