Compound Detail
CHEMBL139249
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Basic Information
| ChEMBL ID | CHEMBL139249 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RARNNEKMSBLJMX-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
335.2
MW (Da)
3.37
ALogP
5
HBA
1
HBD
73.8
PSA (Ų)
0.78
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL3074 | IC50 | 6.8 | 6.8 | 160.0 | 1 |
| Fibroblast growth factor receptor CHEMBL2111391 | IC50 | 6.27 | 6.27 | 540.0 | 1 |
| Platelet-derived growth factor receptor CHEMBL2096980 | IC50 | 6.01 | 6.01 | 980.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 160.0 | nM | 6.8 | Inhibition of mouse c-Src tyrosine kinase | 9784112 |
| Fibroblast growth factor receptor | IC50 | = | 540.0 | nM | 6.27 | Inhibition of mouse fibroblast growth factor receptor tyrosine kinase (FGFr) | 9784112 |
| Platelet-derived growth factor receptor | IC50 | = | 980.0 | nM | 6.01 | Inhibition against of platelet-derived growth factor receptor (PDGFr) | 9784112 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9784112 | 10.1021/jm980398y | Platelet-derived growth factor receptor | 1 |
| 9784112 | 10.1021/jm980398y | Fibroblast growth factor receptor | 1 |
| 9784112 | 10.1021/jm980398y | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine