Assay Detail
Binding
CHEMBL676879
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Inhibition of mouse fibroblast growth factor receptor tyrosine kinase (FGFr)
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Fibroblast growth factor receptor (CHEMBL2111391) ↗| Type | PROTEIN FAMILY |
| Organism | Mus musculus |
Publication
Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.03 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112914 | — | — | 1 | 7.52 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 7.37 |
| CHEMBL136106 | — | — | 1 | 7.06 |
| CHEMBL136244 | — | — | 1 | 6.46 |
| CHEMBL136280 | — | — | 1 | 6.43 |
| CHEMBL337157 | — | — | 1 | 6.30 |
| CHEMBL136775 | — | — | 1 | 6.29 |
| CHEMBL139249 | — | — | 1 | 6.27 |
| CHEMBL138319 | — | — | 1 | 6.24 |
| CHEMBL336093 | — | — | 1 | 6.14 |
| CHEMBL140242 | — | — | 1 | 6.06 |
| CHEMBL134851 | — | — | 1 | 5.96 |
| CHEMBL49596 | — | — | 1 | 5.89 |
| CHEMBL341579 | — | — | 1 | 5.85 |
| CHEMBL434448 | — | — | 1 | 5.82 |
| CHEMBL138994 | — | — | 1 | 5.77 |
| CHEMBL136457 | — | — | 1 | 5.77 |
| CHEMBL136332 | — | — | 1 | 5.54 |
| CHEMBL139040 | — | — | 1 | 5.50 |
| CHEMBL136688 | — | — | 1 | 5.33 |
| CHEMBL137611 | — | — | 1 | 5.30 |
| CHEMBL136874 | — | — | 1 | 5.10 |
| CHEMBL136724 | — | — | 1 | 4.65 |
| CHEMBL343705 | — | — | 1 | - |
| CHEMBL139633 | — | — | 1 | - |
| CHEMBL421928 | — | — | 1 | - |
| CHEMBL337100 | — | — | 1 | - |
| CHEMBL342475 | — | — | 1 | - |
| CHEMBL137388 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112914 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL136106 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL136244 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL136280 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL337157 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL136775 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL139249 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL138319 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL336093 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL140242 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL134851 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL49596 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL341579 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL434448 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL138994 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL136457 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL136332 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL139040 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL136688 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL137611 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL136874 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL136724 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL343705 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL139633 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL421928 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL337100 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL342475 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL137388 | — | IC50 | > | 50000.0 | nM | - |