GABA A receptor alpha-2/beta-2/gamma-2 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P47870. Use UniProt P47870 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P47870 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit beta-2
Review this target as GABA A receptor alpha-2/beta-2/gamma-2, mapped to UniProt P47870. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit beta-2. Sequence length is 512 aa.
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This review treats GABA A receptor alpha-2/beta-2/gamma-2 as ChEMBL target CHEMBL2111413, mapped to UniProt P47870. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether GABA A receptor alpha-2/beta-2/gamma-2 is the right protein anchor across sources, using UniProt P47870 as the stable mapping.
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| Preferred Name | GABA A receptor alpha-2/beta-2/gamma-2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P47870 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit beta-2 |
| UniProt Accession | P47870 |
| Component Type | Protein |
| Sequence Length | 512 aa |
Gamma-aminobutyric acid receptor subunit beta-2
Review this target as GABA A receptor alpha-2/beta-2/gamma-2, mapped to UniProt P47870. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit beta-2. Sequence length is 512 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1709464 | 10.22 | Ki | 0.06 | Preclinical |
| CHEMBL3274851 | 9.82 | Ki | 0.15 | Preclinical |
| CHEMBL475204 | 9.22 | Ki | 0.6 | Preclinical |
| CHEMBL661 | 9.22 | Ki | 0.6 | Approved |
| CHEMBL3246832 | 9.15 | Ki | 0.7 | Preclinical |
| CHEMBL1451229 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL5170217 | 9.0 | Ki | 0.99 | Preclinical |
| CHEMBL5192472 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL5179977 | 8.68 | Ki | 2.1 | Preclinical |
| CHEMBL13280 | 8.6 | Ki | 2.5 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 21 | 69 | 6.0 |
| protein complex format | 5 | 2 | 6.4 |
| cell membrane format | 3 | 26 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 3 | 6.3 |