Compound Detail
CHEMBL1451229
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Basic Information
| ChEMBL ID | CHEMBL1451229 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BUTCFAZTKZDYCN-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
387.7
MW (Da)
4.34
ALogP
4
HBA
0
HBD
43.1
PSA (Ų)
0.62
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 9.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 CHEMBL4523641 | Ki | 9.4 | 9.4 | 0.4 | 1 |
| GABA-A receptor; alpha-1/beta-2/gamma-2 CHEMBL2095172 | Ki | 9.3 | 9.3 | 0.5 | 1 |
| GABA A receptor alpha-3/beta-2/gamma-2 CHEMBL2111339 | Ki | 9.22 | 9.22 | 0.6 | 1 |
| GABA A receptor alpha-2/beta-2/gamma-2 CHEMBL2111413 | Ki | 9.0 | 9.0 | 1.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35218882 | 10.1016/j.bmcl.2022.128637 | GABA-A receptor; alpha-1/beta-2/gamma-2 | 1 |
| 35218882 | 10.1016/j.bmcl.2022.128637 | GABA A receptor alpha-2/beta-2/gamma-2 | 1 |
| 35218882 | 10.1016/j.bmcl.2022.128637 | GABA A receptor alpha-3/beta-2/gamma-2 | 1 |
| 35218882 | 10.1016/j.bmcl.2022.128637 | Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2 | 1 |
Data from ChEMBL 36 via Core Engine