PI3-kinase p110-delta/p85-alpha · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P27986. Use UniProt P27986 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P27986 as the stable identity anchor, then attach disease evidence before program review.
Phosphatidylinositol 3-kinase regulatory subunit alpha
Review this target as PI3-kinase p110-delta/p85-alpha, mapped to UniProt P27986. ChEMBL maps the protein component as Phosphatidylinositol 3-kinase regulatory subunit alpha. Sequence length is 724 aa.
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This review treats PI3-kinase p110-delta/p85-alpha as ChEMBL target CHEMBL2111432, mapped to UniProt P27986. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | PI3-kinase p110-delta/p85-alpha |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P27986 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Phosphatidylinositol 3-kinase regulatory subunit alpha |
| UniProt Accession | P27986 |
| Component Type | Protein |
| Sequence Length | 724 aa |
Phosphatidylinositol 3-kinase regulatory subunit alpha
Review this target as PI3-kinase p110-delta/p85-alpha, mapped to UniProt P27986. ChEMBL maps the protein component as Phosphatidylinositol 3-kinase regulatory subunit alpha. Sequence length is 724 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4850297 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL4869783 | 11.0 | Ki | 0.01 | Preclinical |
| CHEMBL4167702 | 10.9 | Ki | 0.01259 | Preclinical |
| CHEMBL4858875 | 10.8 | Ki | 0.01585 | Preclinical |
| CHEMBL4873390 | 10.6 | Ki | 0.02512 | Preclinical |
| CHEMBL4175571 | 10.6 | Ki | 0.02512 | Preclinical |
| CHEMBL4165185 | 10.6 | Ki | 0.02512 | Preclinical |
| CHEMBL4175737 | 10.5 | Ki | 0.03162 | Preclinical |
| CHEMBL4169192 | 10.4 | Ki | 0.03981 | Preclinical |
| CHEMBL4173087 | 10.3 | Ki | 0.05012 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 74 | 325 | 7.9 |
| cell-based format | 37 | 441 | 7.8 |
| assay format | 15 | 87 | 7.7 |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 6.1 |
| cell-based format | 2 | 27 | 6.1 |