Evidence Snapshot

PI3-kinase p110-delta/p85-alpha

CHEMBL2111432 PROTEIN COMPLEX Homo sapiens

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:25:44Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 14, 2026, 6:25 AM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL2111432

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PI3-kinase p110-delta/p85-alpha as ChEMBL target CHEMBL2111432, mapped to UniProt P27986. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

PI3-kinase p110-delta/p85-alpha

PROTEIN COMPLEX · Homo sapiens

As of 2026-09-13

ChEMBL target ID

CHEMBL2111432

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

UniProt accession

P27986

Phosphatidylinositol 3-kinase regulatory subunit alpha

UniProt accession via ChEMBL component mapping As of 2026-09-13

www.uniprot.org

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why PI3-kinase p110-delta/p85-alpha matters

As of 2026-09-13

PI3-kinase p110-delta/p85-alpha is reviewed as Phosphatidylinositol 3-kinase regulatory subunit alpha (UniProt P27986); the current evidence base includes 5 approved drugs, 1435 compounds, and 131 assays, with lead potency reaching pChEMBL 11.0.

Protein context

Phosphatidylinositol 3-kinase regulatory subunit alpha

Phosphatidylinositol 3-kinase regulatory subunit alpha Sequence length is 724 aa.

Review this target as PI3-kinase p110-delta/p85-alpha, mapped to UniProt P27986. ChEMBL maps the protein component as Phosphatidylinositol 3-kinase regulatory subunit alpha. Sequence length is 724 aa.

Protein source · UniProt accession via ChEMBL component mapping

UniProt P27986 Protein

Disease context

Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record

Activity base

Portfolio and assay base

ChEMBL currently tracks 5 approved drugs, 1435 compounds, and 131 assays for this target. The dominant activity type is IC50. CHEMBL4850297 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL4850297 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine

5 approved pChEMBL 11.0

Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?

Review-ready Target Rationale

One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why PI3-kinase p110-delta/p85-alpha matters before drilling into raw source blocks.

Jump to Review Rationale

Need stable protein naming or accession mapping?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P27986, not just the summarized rationale.

Open Protein Context

Need disease fit or evidence level for program framing?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1435

Total Compounds

131

Total Assays

Approved Drugs

IC50: 1433.0, KI: 117.0, EC50: 1.0, KD: 1.0

Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Compound	pChEMBL	Type	Phase
No preferred name CHEMBL4850297	11.0	Ki	—
No preferred name CHEMBL4869783	11.0	Ki	—
No preferred name CHEMBL4167702	10.9	Ki	—
No preferred name CHEMBL4858875	10.8	Ki	—
No preferred name CHEMBL4873390	10.6	Ki	—