Somatostatin receptor · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Somatostatin receptor shows approved-linked disease relevance led by carcinoid tumor. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P35346. Start with carcinoid tumor, then reuse UniProt P35346 as the stable protein anchor across project notes and exports.
Start with carcinoid tumor, then reuse UniProt P35346 as the stable protein anchor across project notes and exports.
Somatostatin receptor shows approved-linked disease relevance led by carcinoid tumor. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with carcinoid tumor because it currently carries approved-linked support. Linked drugs include OCTREOTIDE ACETATE, SOMATOSTATIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySomatostatin receptor type 5
Review this target as Somatostatin receptor, mapped to UniProt P35346. ChEMBL maps the protein component as Somatostatin receptor type 5. Sequence length is 364 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Somatostatin receptor as ChEMBL target CHEMBL2111436, mapped to UniProt P35346. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Somatostatin receptor is the right protein anchor across sources, using UniProt P35346 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why carcinoid tumor is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Somatostatin receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P35346 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Somatostatin receptor type 5 |
| UniProt Accession | P35346 |
| Component Type | Protein |
| Sequence Length | 364 aa |
Somatostatin receptor type 5
Review this target as Somatostatin receptor, mapped to UniProt P35346. ChEMBL maps the protein component as Somatostatin receptor type 5. Sequence length is 364 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Somatostatin receptor shows approved-linked disease relevance led by carcinoid tumor. 5 more disease programs remain visible in the same review block.
Start review with carcinoid tumor because it currently carries approved-linked support. Linked drugs include OCTREOTIDE ACETATE, SOMATOSTATIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL437296 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL376485 | 9.46 | IC50 | 0.35 | Preclinical |
| CHEMBL408687 | 9.34 | IC50 | 0.46 | Preclinical |
| CHEMBL376484 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL426548 | 9.19 | IC50 | 0.64 | Preclinical |
| CHEMBL1823872 | 9.08 | IC50 | 0.83 | Clinical |
| CHEMBL3350037 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL222699 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL268060 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL65 | 8.66 | IC50 | 2.21 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 12 | 12 | 5.4 |
| cell-based format | 2 | 8 | 8.6 |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 4 | 7.7 |