cAMP-dependent protein kinase A · PROTEIN COMPLEX GROUP · Bos taurus
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As of 2026-09-13Protein identity stays anchored to UniProt P00517. Use UniProt P00517 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00517 as the stable identity anchor, then attach disease evidence before program review.
cAMP-dependent protein kinase catalytic subunit alpha
Review this target as cAMP-dependent protein kinase A, mapped to UniProt P00517. ChEMBL maps the protein component as cAMP-dependent protein kinase catalytic subunit alpha. Sequence length is 351 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats cAMP-dependent protein kinase A as ChEMBL target CHEMBL2111446, mapped to UniProt P00517. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | cAMP-dependent protein kinase A |
| Target Type | PROTEIN COMPLEX GROUP |
| Organism | Bos taurus |
| UniProt | P00517 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | cAMP-dependent protein kinase catalytic subunit alpha |
| UniProt Accession | P00517 |
| Component Type | Protein |
| Sequence Length | 351 aa |
cAMP-dependent protein kinase catalytic subunit alpha
Review this target as cAMP-dependent protein kinase A, mapped to UniProt P00517. ChEMBL maps the protein component as cAMP-dependent protein kinase catalytic subunit alpha. Sequence length is 351 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1202518 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL3216643 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL1202525 | 7.41 | IC50 | 39.0 | Preclinical |
| CHEMBL1204095 | 6.44 | IC50 | 360.0 | Preclinical |
| CHEMBL104264 | 6.32 | Ki | 480.0 | Preclinical |
| CHEMBL1202519 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL477 | 4.82 | Ki | 15000.0 | Approved |
| CHEMBL173917 | 4.54 | Ki | 29000.0 | Preclinical |
| CHEMBL173428 | 4.42 | Ki | 38000.0 | Preclinical |
| CHEMBL1204097 | 4.35 | IC50 | 45000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 9 | 11 | 6.1 |