Review anchor
cAMP-dependent protein kinase A
PROTEIN COMPLEX GROUP · Bos taurus
As of 2026-09-13
Evidence Snapshot
cAMP-dependent protein kinase A
CHEMBL2111446
PROTEIN COMPLEX GROUP
Bos taurus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats cAMP-dependent protein kinase A as ChEMBL target CHEMBL2111446, mapped to UniProt P00517. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL2111446
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P00517
cAMP-dependent protein kinase catalytic subunit alpha
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why cAMP-dependent protein kinase A matters
cAMP-dependent protein kinase A is reviewed as cAMP-dependent protein kinase catalytic subunit alpha (UniProt P00517); the current evidence base includes 1 approved drug, 28 compounds, and 9 assays, with lead potency reaching pChEMBL 8.7.
Protein context
cAMP-dependent protein kinase catalytic subunit alpha
cAMP-dependent protein kinase catalytic subunit alpha Sequence length is 351 aa.
Review this target as cAMP-dependent protein kinase A, mapped to UniProt P00517. ChEMBL maps the protein component as cAMP-dependent protein kinase catalytic subunit alpha. Sequence length is 351 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P00517
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 1 approved drug, 28 compounds, and 9 assays for this target. The dominant activity type is IC50. CHEMBL1202518 is the current potency anchor at pChEMBL 8.7.
Use CHEMBL1202518 as the tractability anchor when discussing potency (pChEMBL 8.7).
Activity source · ChEMBL 36 via Core Engine
1 approved
pChEMBL 8.7
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why cAMP-dependent protein kinase A matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P00517, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
28
Total Compounds
9
Total Assays
1
Approved Drugs
IC50: 20.0, KI: 5.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL1202518
|
8.7 | IC50 | — |
|
|
No preferred name
CHEMBL3216643
|
8.3 | IC50 | — |
|
|
No preferred name
CHEMBL1202525
|
7.4 | IC50 | — |
|
|
No preferred name
CHEMBL1204095
|
6.4 | IC50 | — |
|
|
No preferred name
CHEMBL104264
|
6.3 | Ki | — |
Source Header