Bacterial DNA-directed RNA polymerase · PROTEIN COMPLEX · Bacteria
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Bacterial DNA-directed RNA polymerase shows approved-linked disease relevance led by HIV infection. 5 more disease programs remain visible in the same review block. 4 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P0A8V2. Start with HIV infection, then reuse UniProt P0A8V2 as the stable protein anchor across project notes and exports.
Start with HIV infection, then reuse UniProt P0A8V2 as the stable protein anchor across project notes and exports.
Bacterial DNA-directed RNA polymerase shows approved-linked disease relevance led by HIV infection. 5 more disease programs remain visible in the same review block. 4 linked drugs remain visible in the same block.
Start review with HIV infection because it currently carries approved-linked support. Linked drugs include RIFABUTIN, RIFAMPIN, RIFAPENTINE, RIFAXIMIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyDNA-directed RNA polymerase subunit beta
Review this target as Bacterial DNA-directed RNA polymerase, mapped to UniProt P0A8V2. ChEMBL maps the protein component as DNA-directed RNA polymerase subunit beta. Sequence length is 1342 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Bacterial DNA-directed RNA polymerase as ChEMBL target CHEMBL2364672, mapped to UniProt P0A8V2. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Bacterial DNA-directed RNA polymerase is the right protein anchor across sources, using UniProt P0A8V2 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why HIV infection is currently framed as approved-linked support. It currently carries 4 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Bacterial DNA-directed RNA polymerase |
| Target Type | PROTEIN COMPLEX |
| Organism | Bacteria |
| UniProt | P0A8V2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA-directed RNA polymerase subunit beta |
| UniProt Accession | P0A8V2 |
| Component Type | Protein |
| Sequence Length | 1342 aa |
DNA-directed RNA polymerase subunit beta
Review this target as Bacterial DNA-directed RNA polymerase, mapped to UniProt P0A8V2. ChEMBL maps the protein component as DNA-directed RNA polymerase subunit beta. Sequence length is 1342 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Bacterial DNA-directed RNA polymerase shows approved-linked disease relevance led by HIV infection. 5 more disease programs remain visible in the same review block.
Start review with HIV infection because it currently carries approved-linked support. Linked drugs include RIFABUTIN, RIFAMPIN, RIFAPENTINE, RIFAXIMIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL7568 | 4.7 | IC50 | 20000.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 32 | 1 | 4.7 |