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Target Snapshot

CHEMBL2366241 Target Snapshot

ARH-77 · CELL-LINE · Homo sapiens

110Compounds
18Assays
13Approved Drugs
114.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ARH-77 as ChEMBL target CHEMBL2366241. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ARH-77
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366241
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ARH-77 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelARH-77
UniProt AccessionN/A

ARH-77

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as ARH-77.

Review nameARH-77
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

13
Approved
6
Phase III
7
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50113.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL888 10.15 IC50 0.07107 Approved
CHEMBL325041 8.62 IC50 2.385 Clinical
CHEMBL4248209 8.43 IC50 3.68 Preclinical
CHEMBL4241473 8.33 IC50 4.7 Preclinical
CHEMBL4246864 8.29 IC50 5.12 Preclinical
CHEMBL4246480 8.27 IC50 5.32 Preclinical
CHEMBL4245244 8.22 IC50 6.07 Preclinical
CHEMBL94657 8.21 IC50 6.13 Clinical
CHEMBL4238198 8.12 IC50 7.59 Preclinical
CHEMBL4243375 8.04 IC50 9.1 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
6
5.5
5
6.0
6
6.5
8
7.0
6
7.5
11
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
Assay Landscape

Assay Landscape

18
Total Assays
99
Tested Compounds
1
Assay Types
Functional — 18 assays, 99 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 99 6.1
organism-based format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine