Compound Detail

CHEMBL4238198

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CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1CCCCC1)B(O)O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL4238198
Phase	Preclinical
Structure Type	MOL
InChI Key	PLJIGMVETKDHOI-OALUTQOASA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

388.3

MW (Da)

First in Class Prodrug

Molecular Formula	C21H33BN2O4
MW	388.32

IC50 4 meas. best 8.49

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Proteasome Macropain subunit MB1 CHEMBL4662	IC50	8.49	8.49	3.2	1
U-266 CHEMBL2366315	IC50	8.22	8.22	6.0	1
ARH-77 CHEMBL2366241	IC50	8.12	8.12	7.6	1
RPMI-8226 CHEMBL614882	IC50	7.92	7.92	11.9	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Proteasome Macropain subunit MB1	IC50	=	3.22	nM	8.49	Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-L...	29934218
U-266	IC50	=	5.97	nM	8.22	Cytotoxicity against human U266B1 cells assessed as reduction in cell viability ...	29934218
ARH-77	IC50	=	7.59	nM	8.12	Cytotoxicity against human ARH77 cells assessed as reduction in cell viability a...	29934218
RPMI-8226	IC50	=	11.93	nM	7.92	Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viabilit...	29934218

PubMed	DOI	Target Context	# Activities
29934218	10.1016/j.bmc.2018.06.020	ARH-77	1
29934218	10.1016/j.bmc.2018.06.020	U-266	1
29934218	10.1016/j.bmc.2018.06.020	RPMI-8226	1
29934218	10.1016/j.bmc.2018.06.020	Proteasome Macropain subunit MB1	1

Data from ChEMBL 36 via Core Engine