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Target Snapshot

CHEMBL2366265 Target Snapshot

COLO-320-HSR · CELL-LINE · Homo sapiens

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135Compounds
10Assays
26Approved Drugs
137.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats COLO-320-HSR as ChEMBL target CHEMBL2366265. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
COLO-320-HSR
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366265
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether COLO-320-HSR still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCOLO-320-HSR
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCOLO-320-HSR
UniProt AccessionN/A

COLO-320-HSR

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as COLO-320-HSR.

Review nameCOLO-320-HSR
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

26
Approved
14
Phase III
9
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50136.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL325041 8.41 IC50 3.916 Clinical
CHEMBL94657 8.28 IC50 5.207 Clinical
CHEMBL575448 7.96 IC50 11.0 Clinical
CHEMBL5275764 7.64 IC50 23.0 Preclinical
CHEMBL514499 7.55 IC50 28.11 Preclinical
CHEMBL96926 7.32 IC50 47.96 Preclinical
CHEMBL2107358 7.28 IC50 52.89 Clinical
CHEMBL34259 7.28 IC50 52.38 Approved
CHEMBL65 7.21 IC50 62.09 Preclinical
CHEMBL300389 7.08 IC50 82.86 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
6
5.5
12
6.0
8
6.5
6
7.0
3
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

10
Total Assays
132
Tested Compounds
1
Assay Types
Functional — 10 assays, 132 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 132 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine