Compound Detail
CHEMBL5275764
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5275764 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FHIDNBAQOFJWCA-MNCSTQPFSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
262.2
MW (Da)
-2.71
ALogP
7
HBA
4
HBD
124.8
PSA (Ų)
0.46
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| COLO-320-HSR CHEMBL2366265 | IC50 | 7.64 | 7.64 | 23.0 | 1 |
| HT-29 CHEMBL384 | IC50 | 7.39 | 7.39 | 41.0 | 1 |
| DLD-1 CHEMBL614285 | IC50 | 7.28 | 7.28 | 52.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| COLO-320-HSR | IC50 | = | 23.0 | nM | 7.64 | Antiproliferative activity against human COLO 320HSR cells assessed as cell grow... | 32927231 |
| HT-29 | IC50 | = | 41.0 | nM | 7.39 | Antiproliferative activity against human HT-29 cells assessed as cell growth inh... | 32927231 |
| DLD-1 | IC50 | = | 52.0 | nM | 7.28 | Antiproliferative activity against human DLD-1 cells assessed as cell growth inh... | 32927231 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32927231 | 10.1016/j.ejmech.2020.112801 | DLD-1 | 1 |
| 32927231 | 10.1016/j.ejmech.2020.112801 | COLO-320-HSR | 1 |
| 32927231 | 10.1016/j.ejmech.2020.112801 | HT-29 | 1 |
Data from ChEMBL 36 via Core Engine