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Target Snapshot

CHEMBL2366486 Target Snapshot

Glutamine synthetase · SINGLE PROTEIN · Oryza sativa

18Compounds
9Assays
0Approved Drugs
30.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q01HZ7. Use UniProt Q01HZ7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q01HZ7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glutamine synthetase as ChEMBL target CHEMBL2366486, mapped to UniProt Q01HZ7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glutamine synthetase
SINGLE PROTEIN · Oryza sativa
As of 2026-09-14
ChEMBL target ID
CHEMBL2366486
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q01HZ7
Glutamine synthetase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glutamine synthetase is the right protein anchor across sources, using UniProt Q01HZ7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlutamine synthetase
UniProt AccessionQ01HZ7
Component TypeProtein
Sequence Length428 aa

Glutamine synthetase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glutamine synthetase, mapped to UniProt Q01HZ7. Sequence length is 428 aa.

Mapped IDQ01HZ7
Review nameGlutamine synthetase
OrganismOryza sativa
Assay Mix

Activity Type Distribution

IC5030.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL55518 6.4 IC50 396.0 Preclinical
CHEMBL2251375 5.84 IC50 1450.0 Preclinical
CHEMBL450938 5.7 IC50 1990.0 Preclinical
CHEMBL145114 4.36 IC50 44000.0 Preclinical
CHEMBL2251373 4.19 IC50 64000.0 Preclinical
CHEMBL54714 4.16 IC50 69000.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
2
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

9
Total Assays
11
Tested Compounds
1
Assay Types
Binding — 9 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 9 11 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine