Compound Detail
CHEMBL145114
PHOSPHINOTHRICIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL145114 |
| Name | PHOSPHINOTHRICIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IAJOBQBIJHVGMQ-BYPYZUCNSA-N |
1
Targets
5
Activities
2
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
181.1
MW (Da)
-0.31
ALogP
3
HBA
3
HBD
100.6
PSA (Ų)
0.52
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.36
EC50 2 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamine synthetase CHEMBL2366486 | IC50 | 4.36 | 4.335 | 44000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamine synthetase | IC50 | = | 44000.0 | nM | 4.36 | Inhibition of Oryza sativa cv. Gigante vercellese (rice) glutamine synthetase as... | 15161194 |
| Glutamine synthetase | IC50 | = | 49000.0 | nM | 4.31 | Inhibition of Oryza sativa cv. Gigante vercellese (rice) glutamine synthetase af... | 15161194 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15161194 | 10.1021/jf049843q | Glutamine synthetase | 7 |
| 2892937 | 10.1021/jm00397a037 | Glutamine synthetase | 6 |
| 15161194 | 10.1021/jf049843q | Oryza sativa | 6 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 4 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 6 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 7 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 8 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 1 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 5 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 2 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 3 | 1 |
Data from ChEMBL 36 via Core Engine