Assay Detail
Binding
CHEMBL3075491
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Inhibition of Oryza sativa cv. Gigante vercellese (rice) glutamine synthetase assessed as inhibition of glutamine synthesis from glutamic acid after 15 min by biosynthetic assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryza sativa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Herbicidal pyridyl derivatives of aminomethylene-bisphosphonic acid inhibit plant glutamine synthetase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.30 | 4.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55518 | (3,5-DICHLOROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.48 |
| CHEMBL145114 | PHOSPHINOTHRICIN | — | 1 | 4.36 |
| CHEMBL2251373 | — | — | 1 | 4.19 |
| CHEMBL54714 | — | — | 1 | 4.16 |
| CHEMBL299443 | (4-HYDROXYPHENETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | - |
| CHEMBL2251371 | 3-(DIPHOSPHONOMETHYLAMINO)BENZOIC ACID | — | 1 | - |
| CHEMBL450938 | (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | - |
| CHEMBL2251375 | 2-(DIPHOSPHONOMETHYLAMINO)NICOTINIC ACID | — | 1 | - |
| CHEMBL2440439 | (P-TOLYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | - |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | - |
| CHEMBL291736 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55518 | (3,5-DICHLOROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL145114 | PHOSPHINOTHRICIN | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL2251373 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL54714 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL299443 | (4-HYDROXYPHENETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 4470000.0 | nM | - |
| CHEMBL2251371 | 3-(DIPHOSPHONOMETHYLAMINO)BENZOIC ACID | IC50 | = | 1800000.0 | nM | - |
| CHEMBL450938 | (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 738000.0 | nM | - |
| CHEMBL2251375 | 2-(DIPHOSPHONOMETHYLAMINO)NICOTINIC ACID | IC50 | = | 334000.0 | nM | - |
| CHEMBL2440439 | (P-TOLYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 170000.0 | nM | - |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 1110000.0 | nM | - |
| CHEMBL291736 | — | IC50 | = | 243000.0 | nM | - |