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Target Snapshot

CHEMBL2370 Target Snapshot

Sodium-dependent noradrenaline transporter · SINGLE PROTEIN · Mus musculus

39Compounds
6Assays
7Approved Drugs
39.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt O55192. Use UniProt O55192 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O55192 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sodium-dependent noradrenaline transporter as ChEMBL target CHEMBL2370, mapped to UniProt O55192. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sodium-dependent noradrenaline transporter
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2370
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O55192
Sodium-dependent noradrenaline transporter
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sodium-dependent noradrenaline transporter is the right protein anchor across sources, using UniProt O55192 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium-dependent noradrenaline transporter
UniProt AccessionO55192
Component TypeProtein
Sequence Length617 aa

Sodium-dependent noradrenaline transporter

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Sodium-dependent noradrenaline transporter, mapped to UniProt O55192. Sequence length is 617 aa.

Mapped IDO55192
Review nameSodium-dependent noradrenaline transporter
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

7
Approved
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC506.0
KI33.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL35184 9.22 Ki 0.6 Preclinical
CHEMBL285506 9.17 Ki 0.68 Preclinical
CHEMBL330666 9.03 Ki 0.94 Preclinical
CHEMBL94535 8.8 Ki 1.6 Preclinical
CHEMBL1173532 8.8 Ki 1.585 Preclinical
CHEMBL327790 8.74 Ki 1.8 Preclinical
CHEMBL96362 8.49 Ki 3.2 Preclinical
CHEMBL94711 8.48 Ki 3.3 Preclinical
CHEMBL94665 8.35 Ki 4.5 Preclinical
CHEMBL539803 8.22 Ki 6.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
2
5.5
6
6.0
4
6.5
5
7.0
9
7.5
4
8.0
4
8.5
3
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PAROXETINE
CHEMBL490
Approved 1992
CLOMIPRAMINE
CHEMBL415
Approved 1989
FLUOXETINE
CHEMBL41
Approved 1987
CYPROHEPTADINE
CHEMBL516
Approved 1961
IMIPRAMINE
CHEMBL11
Approved 1959
AMPHETAMINE
CHEMBL405
Approved 1955
Assay Landscape

Assay Landscape

6
Total Assays
35
Tested Compounds
2
Assay Types
Binding — 4 assays, 35 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 2 7 6.4
cell-based format 1 2 7.2
single protein format 1 26 7.8
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine