Review anchor
Sodium-dependent noradrenaline transporter
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
Evidence Snapshot
Sodium-dependent noradrenaline transporter
CHEMBL2370
SINGLE PROTEIN
Mus musculus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sodium-dependent noradrenaline transporter as ChEMBL target CHEMBL2370, mapped to UniProt O55192. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL2370
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O55192
Sodium-dependent noradrenaline transporter
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Sodium-dependent noradrenaline transporter matters
Sodium-dependent noradrenaline transporter is reviewed as Sodium-dependent noradrenaline transporter (UniProt O55192); the current evidence base includes 7 approved drugs, 39 compounds, and 6 assays, with lead potency reaching pChEMBL 9.2.
Protein context
Sodium-dependent noradrenaline transporter
Sodium-dependent noradrenaline transporter Sequence length is 617 aa.
Review this target as Sodium-dependent noradrenaline transporter, mapped to UniProt O55192. Sequence length is 617 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt O55192
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 7 approved drugs, 39 compounds, and 6 assays for this target. The dominant activity type is KI. CHEMBL35184 is the current potency anchor at pChEMBL 9.2.
Use CHEMBL35184 as the tractability anchor when discussing potency (pChEMBL 9.2).
Activity source · ChEMBL 36 via Core Engine
7 approved
pChEMBL 9.2
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Sodium-dependent noradrenaline transporter matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt O55192, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
39
Total Compounds
6
Total Assays
7
Approved Drugs
IC50: 6.0, KI: 33.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL35184
|
9.2 | Ki | — |
|
|
No preferred name
CHEMBL285506
|
9.2 | Ki | — |
|
|
No preferred name
CHEMBL330666
|
9.0 | Ki | — |
|
|
No preferred name
CHEMBL94535
|
8.8 | Ki | — |
|
|
No preferred name
CHEMBL1173532
|
8.8 | Ki | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
PAROXETINE
CHEMBL490
|
1992 |
|
|
CLOMIPRAMINE
CHEMBL415
|
1989 |
|
|
FLUOXETINE
CHEMBL41
|
1987 |
|
|
CYPROHEPTADINE
CHEMBL516
|
1961 |
|
|
IMIPRAMINE
CHEMBL11
|
1959 |
|
|
AMPHETAMINE
CHEMBL405
|
1955 |
Source Header