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Target Snapshot

CHEMBL2426 Target Snapshot

Casein kinase I isoform gamma-1 · SINGLE PROTEIN · Homo sapiens

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1,770Compounds
248Assays
3Approved Drugs
978.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q9HCP0. Use UniProt Q9HCP0 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9HCP0 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Casein kinase I isoform gamma-1 as ChEMBL target CHEMBL2426, mapped to UniProt Q9HCP0. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Casein kinase I isoform gamma-1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2426
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9HCP0
Casein kinase I isoform gamma-1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Casein kinase I isoform gamma-1 is the right protein anchor across sources, using UniProt Q9HCP0 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCasein kinase I isoform gamma-1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9HCP0
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCasein kinase I isoform gamma-1
UniProt AccessionQ9HCP0
Component TypeProtein
Sequence Length422 aa

Casein kinase I isoform gamma-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Casein kinase I isoform gamma-1, mapped to UniProt Q9HCP0. Sequence length is 422 aa.

Mapped IDQ9HCP0
Review nameCasein kinase I isoform gamma-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
2
Phase III
9
Phase II
8
Phase I
Assay Mix

Activity Type Distribution

IC5036.0
KI563.0
KD379.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL371206 8.4 Ki 3.981 Preclinical
CHEMBL2003638 7.9 Ki 12.59 Preclinical
CHEMBL1969588 7.8 Ki 15.85 Preclinical
CHEMBL1999931 7.8 Ki 15.85 Preclinical
CHEMBL1986139 7.7 Ki 19.95 Preclinical
CHEMBL1973893 7.7 Ki 19.95 Preclinical
CHEMBL1967531 7.7 Ki 19.95 Preclinical
CHEMBL1973098 7.7 Ki 19.95 Preclinical
CHEMBL1984586 7.7 Ki 19.95 Preclinical
CHEMBL1997340 7.7 Ki 19.95 Preclinical
Distribution

pChEMBL Value Distribution

45
5.0
82
5.5
52
6.0
25
6.5
13
7.0
16
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

RUXOLITINIB
CHEMBL1789941
Approved 2011
Properties Compare Identifier
SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

248
Total Assays
187
Tested Compounds
2
Assay Types
Binding — 247 assays, 39 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 196 30 5.7
assay format 32 0 —
cell-based format 10 0 —
subcellular format 9 9 5.9
Functional — 1 assays, 187 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 187 6.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine