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Target Snapshot

CHEMBL2446 Target Snapshot

Corticotropin-releasing factor receptor 1 · SINGLE PROTEIN · Mus musculus

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62Compounds
6Assays
0Approved Drugs
60.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P35347. Use UniProt P35347 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P35347 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Corticotropin-releasing factor receptor 1 as ChEMBL target CHEMBL2446, mapped to UniProt P35347. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Corticotropin-releasing factor receptor 1
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL2446
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P35347
Corticotropin-releasing factor receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Corticotropin-releasing factor receptor 1 is the right protein anchor across sources, using UniProt P35347 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCorticotropin-releasing factor receptor 1
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtP35347
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCorticotropin-releasing factor receptor 1
UniProt AccessionP35347
Component TypeProtein
Sequence Length415 aa

Corticotropin-releasing factor receptor 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Corticotropin-releasing factor receptor 1, mapped to UniProt P35347. Sequence length is 415 aa.

Mapped IDP35347
Review nameCorticotropin-releasing factor receptor 1
OrganismMus musculus
Assay Mix

Activity Type Distribution

EC5060.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3775924 9.38 EC50 0.42 Preclinical
CHEMBL3774395 9.36 EC50 0.44 Preclinical
CHEMBL4299295 9.35 EC50 0.45 Preclinical
CHEMBL3774939 9.15 EC50 0.7 Preclinical
CHEMBL3775796 9.1 EC50 0.8 Preclinical
CHEMBL439883 7.75 EC50 17.6 Preclinical
CHEMBL440057 7.7 EC50 20.0 Preclinical
CHEMBL413414 7.32 EC50 48.1 Preclinical
CHEMBL267635 7.28 EC50 52.2 Preclinical
CHEMBL411590 7.2 EC50 63.4 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
15
6.0
13
6.5
14
7.0
2
7.5
0
8.0
0
8.5
5
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

6
Total Assays
44
Tested Compounds
2
Assay Types
Binding — 4 assays, 44 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 3 0 —
single protein format 1 44 6.8
Functional — 2 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0 —
cell-based format 1 5 9.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine