Compound Detail

CHEMBL440057

HUMAN CORTICOTROPIN RELEASING FACTOR

Enter ChEMBL ID:

Free Research Context This compound will appear in recent viewed items on the research home for this browser.

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(=O)O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL440057
Name	HUMAN CORTICOTROPIN RELEASING FACTOR
Phase	Preclinical
Structure Type	BOTH
InChI Key	PNMZQWKBJIQQJL-FAUHKOHMSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

4758.5

MW (Da)

Drug Information

Molecule Type	Protein
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C208H343N59O64S2
MW	4758.52

Activity Summary

IC50 4 meas. best 9.0

EC50 2 meas. best 7.7

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Corticotropin-releasing factor receptor 1 CHEMBL1800	IC50	9.0	9.0	1.0	1
Corticotropin-releasing factor receptor 2 CHEMBL3581	IC50	8.68	8.68	2.1	1
Corticotropin-releasing factor receptor 2 CHEMBL4069	IC50	8.21	8.21	6.2	1
Corticotropin-releasing factor receptor 1 CHEMBL4649	IC50	7.92	7.92	11.9	1
Corticotropin-releasing factor receptor 1 CHEMBL2446	EC50	7.7	7.7	20.0	1
Corticotropin-releasing factor receptor 2 CHEMBL2253	EC50	7.31	7.31	49.2	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Corticotropin-releasing factor receptor 1	IC50	=	0.99	nM	9.0	Inhibition of recombinant corticotropin releasing factor receptor 1 assayed usin...	12361401
Corticotropin-releasing factor receptor 2	IC50	=	2.07	nM	8.68	Compound was evaluated for affinity towards Corticotropin releasing factor recep...	12361401
Corticotropin-releasing factor receptor 2	IC50	=	6.2	nM	8.21	Inhibition of recombinant human corticotropin releasing factor receptor 2 beta (...	12361401
Corticotropin-releasing factor receptor 1	IC50	=	11.9	nM	7.92	Compound was evaluated for affinity towards Corticotropin releasing factor recep...	12361401
Corticotropin-releasing factor receptor 1	EC50	=	20.0	nM	7.7	In vitro effective concentration for mouse corticotropin releasing factor 1 rece...	15634020
Corticotropin-releasing factor receptor 2	EC50	=	49.2	nM	7.31	In vitro effective concentration for mouse corticotropin releasing factor 2 rece...	15634020

Literature References

PubMed	DOI	Target Context	# Activities
12361401	10.1021/jm0202122	Corticotropin-releasing factor receptor 1	2
12361401	10.1021/jm0202122	Corticotropin-releasing factor receptor 2	2
15634020	10.1021/jm049490m	Corticotropin-releasing factor receptor 2	2
15634020	10.1021/jm049490m	Corticotropin-releasing factor receptor 1	2

Data from ChEMBL 36 via Core Engine