Assay Detail
Binding
CHEMBL829879
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL2446) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of corticotropin releasing factor 2 receptor selective sauvagine analogues for treatment of skeletal muscle atrophy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 55 | 6.78 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439883 | SAUVAGINE | — | 1 | 7.75 |
| CHEMBL440057 | HUMAN CORTICOTROPIN RELEASING FACTOR | — | 1 | 7.70 |
| CHEMBL413414 | — | — | 1 | 7.32 |
| CHEMBL267635 | — | — | 1 | 7.28 |
| CHEMBL438948 | — | — | 1 | 7.20 |
| CHEMBL411590 | — | — | 1 | 7.20 |
| CHEMBL438928 | — | — | 1 | 7.19 |
| CHEMBL412026 | — | — | 1 | 7.17 |
| CHEMBL438939 | — | — | 1 | 7.12 |
| CHEMBL428824 | — | — | 1 | 7.11 |
| CHEMBL436912 | — | — | 1 | 7.09 |
| CHEMBL436914 | — | — | 1 | 7.07 |
| CHEMBL430078 | — | — | 1 | 7.02 |
| CHEMBL414711 | — | — | 1 | 7.02 |
| CHEMBL410347 | — | — | 1 | 7.01 |
| CHEMBL264275 | — | — | 1 | 7.00 |
| CHEMBL442112 | — | — | 1 | 6.99 |
| CHEMBL263862 | — | — | 1 | 6.99 |
| CHEMBL427811 | — | — | 1 | 6.97 |
| CHEMBL427923 | — | — | 1 | 6.97 |
| CHEMBL437089 | — | — | 1 | 6.95 |
| CHEMBL438391 | — | — | 1 | 6.94 |
| CHEMBL414130 | — | — | 1 | 6.79 |
| CHEMBL438220 | — | — | 1 | 6.73 |
| CHEMBL410568 | — | — | 1 | 6.72 |
| CHEMBL428127 | — | — | 1 | 6.66 |
| CHEMBL415130 | — | — | 1 | 6.63 |
| CHEMBL438601 | — | — | 1 | 6.58 |
| CHEMBL412296 | — | — | 1 | 6.51 |
| CHEMBL429403 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439883 | SAUVAGINE | EC50 | = | 17.6 | nM | 7.75 |
| CHEMBL440057 | HUMAN CORTICOTROPIN RELEASING FACTOR | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL413414 | — | EC50 | = | 48.1 | nM | 7.32 |
| CHEMBL267635 | — | EC50 | = | 52.2 | nM | 7.28 |
| CHEMBL438948 | — | EC50 | = | 63.6 | nM | 7.20 |
| CHEMBL411590 | — | EC50 | = | 63.4 | nM | 7.20 |
| CHEMBL438928 | — | EC50 | = | 64.9 | nM | 7.19 |
| CHEMBL412026 | — | EC50 | = | 67.9 | nM | 7.17 |
| CHEMBL438939 | — | EC50 | = | 76.2 | nM | 7.12 |
| CHEMBL428824 | — | EC50 | = | 78.4 | nM | 7.11 |
| CHEMBL436912 | — | EC50 | = | 80.9 | nM | 7.09 |
| CHEMBL436914 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL430078 | — | EC50 | = | 94.6 | nM | 7.02 |
| CHEMBL414711 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL410347 | — | EC50 | = | 98.4 | nM | 7.01 |
| CHEMBL264275 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL442112 | — | EC50 | = | 102.5 | nM | 6.99 |
| CHEMBL263862 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL427811 | — | EC50 | = | 107.5 | nM | 6.97 |
| CHEMBL427923 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL437089 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL438391 | — | EC50 | = | 115.5 | nM | 6.94 |
| CHEMBL414130 | — | EC50 | = | 162.5 | nM | 6.79 |
| CHEMBL438220 | — | EC50 | = | 187.5 | nM | 6.73 |
| CHEMBL410568 | — | EC50 | = | 188.5 | nM | 6.72 |
| CHEMBL428127 | — | EC50 | = | 220.5 | nM | 6.66 |
| CHEMBL415130 | — | EC50 | = | 236.5 | nM | 6.63 |
| CHEMBL438601 | — | EC50 | = | 265.5 | nM | 6.58 |
| CHEMBL412296 | — | EC50 | = | 311.5 | nM | 6.51 |
| CHEMBL429403 | — | EC50 | = | 325.0 | nM | 6.49 |
| CHEMBL427611 | — | EC50 | = | 366.5 | nM | 6.44 |
| CHEMBL428809 | — | EC50 | = | 384.5 | nM | 6.42 |
| CHEMBL428296 | — | EC50 | = | 408.0 | nM | 6.39 |
| CHEMBL268549 | — | EC50 | = | 403.5 | nM | 6.39 |
| CHEMBL409748 | — | EC50 | = | 423.0 | nM | 6.37 |
| CHEMBL427792 | — | EC50 | = | 445.0 | nM | 6.35 |
| CHEMBL438760 | — | EC50 | = | 447.0 | nM | 6.35 |
| CHEMBL429547 | — | EC50 | = | 562.0 | nM | 6.25 |
| CHEMBL410814 | — | EC50 | = | 581.5 | nM | 6.24 |
| CHEMBL429719 | — | EC50 | = | 606.0 | nM | 6.22 |
| CHEMBL438210 | — | EC50 | = | 608.0 | nM | 6.22 |
| CHEMBL437289 | — | EC50 | = | 706.5 | nM | 6.15 |
| CHEMBL439102 | — | EC50 | = | 756.0 | nM | 6.12 |
| CHEMBL441929 | — | EC50 | = | 943.5 | nM | 6.03 |
| CHEMBL439887 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL414568 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL429243 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL409626 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL411474 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL411961 | — | EC50 | > | 1000.0 | nM | - |