Compound Detail
CHEMBL429547
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CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL429547 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | NVTIAPZTMVCJHZ-QYKYKQDTSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
4667.5
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 2 CHEMBL2253 | EC50 | 7.63 | 7.63 | 23.4 | 1 |
| Corticotropin-releasing factor receptor 1 CHEMBL2446 | EC50 | 6.25 | 6.25 | 562.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 2 | EC50 | = | 23.4 | nM | 7.63 | In vitro effective concentration for mouse corticotropin releasing factor 2 rece... | 15634020 |
| Corticotropin-releasing factor receptor 1 | EC50 | = | 562.0 | nM | 6.25 | In vitro effective concentration for mouse corticotropin releasing factor 1 rece... | 15634020 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15634020 | 10.1021/jm049490m | Corticotropin-releasing factor receptor 2 | 2 |
| 15634020 | 10.1021/jm049490m | Corticotropin-releasing factor receptor 1 | 2 |
| 15634020 | 10.1021/jm049490m | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine