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Target Snapshot

CHEMBL2456 Target Snapshot

Lutropin-choriogonadotropic hormone receptor · SINGLE PROTEIN · Rattus norvegicus

87Compounds
28Assays
1Approved Drugs
84.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P16235. Use UniProt P16235 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P16235 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lutropin-choriogonadotropic hormone receptor as ChEMBL target CHEMBL2456, mapped to UniProt P16235. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lutropin-choriogonadotropic hormone receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL2456
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P16235
Lutropin-choriogonadotropic hormone receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lutropin-choriogonadotropic hormone receptor is the right protein anchor across sources, using UniProt P16235 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLutropin-choriogonadotropic hormone receptor
UniProt AccessionP16235
Component TypeProtein
Sequence Length700 aa

Lutropin-choriogonadotropic hormone receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Lutropin-choriogonadotropic hormone receptor, mapped to UniProt P16235. Sequence length is 700 aa.

Mapped IDP16235
Review nameLutropin-choriogonadotropic hormone receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC506.0
KI48.0
KD30.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL412984 10.74 Ki 0.0182 Preclinical
CHEMBL407606 10.61 Ki 0.02455 Preclinical
CHEMBL407123 10.37 Ki 0.04266 Preclinical
CHEMBL405737 10.11 Ki 0.07762 Preclinical
CHEMBL385042 10.03 Ki 0.09333 Preclinical
CHEMBL275935 9.87 Kd 0.1349 Preclinical
CHEMBL415571 9.81 Ki 0.1549 Preclinical
CHEMBL385468 9.73 Ki 0.1862 Preclinical
CHEMBL429240 9.68 Ki 0.2089 Preclinical
CHEMBL216617 9.55 Ki 0.2818 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
5
5.5
6
6.0
8
6.5
10
7.0
10
7.5
11
8.0
16
8.5
6
9.0
5
9.5
pChEMBL
Approved Drugs

Approved Drugs

GONADORELIN
CHEMBL1007
Approved 1982
Assay Landscape

Assay Landscape

28
Total Assays
52
Tested Compounds
2
Assay Types
Binding — 18 assays, 52 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 10 0
cell-based format 5 40 8.0
single protein format 2 12 9.5
assay format 1 0
Functional — 10 assays, 31 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 5 1 9.2
organism-based format 3 25 7.4
cell-based format 2 5 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine