Review anchor
Lutropin-choriogonadotropic hormone receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
Evidence Snapshot
Lutropin-choriogonadotropic hormone receptor
CHEMBL2456
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lutropin-choriogonadotropic hormone receptor as ChEMBL target CHEMBL2456, mapped to UniProt P16235. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL2456
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P16235
Lutropin-choriogonadotropic hormone receptor
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Lutropin-choriogonadotropic hormone receptor matters
Lutropin-choriogonadotropic hormone receptor is reviewed as Lutropin-choriogonadotropic hormone receptor (UniProt P16235); the current evidence base includes 1 approved drug, 87 compounds, and 28 assays, with lead potency reaching pChEMBL 10.7.
Protein context
Lutropin-choriogonadotropic hormone receptor
Lutropin-choriogonadotropic hormone receptor Sequence length is 700 aa.
Review this target as Lutropin-choriogonadotropic hormone receptor, mapped to UniProt P16235. Sequence length is 700 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P16235
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 1 approved drug, 87 compounds, and 28 assays for this target. The dominant activity type is KI. CHEMBL412984 is the current potency anchor at pChEMBL 10.7.
Use CHEMBL412984 as the tractability anchor when discussing potency (pChEMBL 10.7).
Activity source · ChEMBL 36 via Core Engine
1 approved
pChEMBL 10.7
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Lutropin-choriogonadotropic hormone receptor matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P16235, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
87
Total Compounds
28
Total Assays
1
Approved Drugs
IC50: 6.0, KI: 48.0, KD: 30.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL412984
|
10.7 | Ki | — |
|
|
No preferred name
CHEMBL407606
|
10.6 | Ki | — |
|
|
No preferred name
CHEMBL407123
|
10.4 | Ki | — |
|
|
No preferred name
CHEMBL405737
|
10.1 | Ki | — |
|
|
No preferred name
CHEMBL385042
|
10.0 | Ki | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
GONADORELIN
CHEMBL1007
|
1982 |
Source Header