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Evidence Snapshot

Protein kinase C gamma type

CHEMBL2938 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:34Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2938
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein kinase C gamma type as ChEMBL target CHEMBL2938, mapped to UniProt P05129. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein kinase C gamma type
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2938
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P05129
Protein kinase C gamma type
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Protein kinase C gamma type matters

As of 2026-09-13

Protein kinase C gamma type is reviewed as Protein kinase C gamma type (UniProt P05129); the current evidence base includes 1 approved drug, 1809 compounds, and 324 assays, with lead potency reaching pChEMBL 9.8.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 1 approved drug, 1809 compounds, and 324 assays for this target. The dominant activity type is KI. CHEMBL337834 is the current potency anchor at pChEMBL 9.8.

Use CHEMBL337834 as the tractability anchor when discussing potency (pChEMBL 9.8).

Activity source · ChEMBL 36 via Core Engine
1 approved pChEMBL 9.8
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Protein kinase C gamma type matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P05129, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1809
Total Compounds
324
Total Assays
1
Approved Drugs
IC50: 253.0, KI: 851.0, KD: 11.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL337834
 9.8 Kd —
No preferred name
CHEMBL2148106
 9.4 Ki —
No preferred name
CHEMBL388978
 9.3 IC50 —
No preferred name
CHEMBL1256416
 9.2 Ki —
No preferred name
CHEMBL5175742
 9.2 Ki —

Approved Drugs

Structure Compound First Approval
ENTRECTINIB
CHEMBL1983268
 2019
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:34Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL2938