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Target Snapshot

CHEMBL2939 Target Snapshot

Mitogen-activated protein kinase 13 · SINGLE PROTEIN · Homo sapiens

2,086Compounds
398Assays
1Approved Drugs
1,076.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt O15264. Use UniProt O15264 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O15264 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mitogen-activated protein kinase 13 as ChEMBL target CHEMBL2939, mapped to UniProt O15264. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mitogen-activated protein kinase 13
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2939
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O15264
Mitogen-activated protein kinase 13
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mitogen-activated protein kinase 13 is the right protein anchor across sources, using UniProt O15264 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMitogen-activated protein kinase 13
UniProt AccessionO15264
Component TypeProtein
Sequence Length365 aa

Mitogen-activated protein kinase 13

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Mitogen-activated protein kinase 13, mapped to UniProt O15264. Sequence length is 365 aa.

Mapped IDO15264
Review nameMitogen-activated protein kinase 13
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
2
Phase III
7
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50239.0
KI755.0
KD82.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2087507 9.19 IC50 0.64 Preclinical
CHEMBL2087515 9.08 IC50 0.83 Preclinical
CHEMBL2087513 8.8 IC50 1.6 Preclinical
CHEMBL2087524 8.77 IC50 1.7 Preclinical
CHEMBL2087509 8.72 IC50 1.9 Preclinical
CHEMBL2087501 8.7 IC50 2.0 Preclinical
CHEMBL2087503 8.52 IC50 3.0 Preclinical
CHEMBL2087526 8.51 IC50 3.1 Preclinical
CHEMBL561932 8.4 IC50 4.0 Preclinical
CHEMBL5772598 8.22 IC50 6.0 Preclinical
Distribution

pChEMBL Value Distribution

53
5.0
42
5.5
49
6.0
22
6.5
20
7.0
20
7.5
11
8.0
6
8.5
2
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

398
Total Assays
120
Tested Compounds
2
Assay Types
Binding — 397 assays, 96 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 314 89 6.9
assay format 63 7 5.9
cell-based format 12 0
subcellular format 8 0
Functional — 1 assays, 120 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 120 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine