Use UniProt P28720 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL2987 Target Snapshot
Queuine tRNA-ribosyltransferase · SINGLE PROTEIN · Zymomonas mobilis (strain ATCC 31821 / ZM4 / CP4)
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As of 2026-09-14Protein identity stays anchored to UniProt P28720. Use UniProt P28720 as the stable identity anchor, then attach disease evidence before program review.
Queuine tRNA-ribosyltransferase
Review this target as Queuine tRNA-ribosyltransferase, mapped to UniProt P28720. Sequence length is 386 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Queuine tRNA-ribosyltransferase as ChEMBL target CHEMBL2987, mapped to UniProt P28720. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Queuine tRNA-ribosyltransferase is the right protein anchor across sources, using UniProt P28720 as the stable mapping.
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Open Review-ready CardBasic Information
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| Preferred Name | Queuine tRNA-ribosyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Zymomonas mobilis (strain ATCC 31821 / ZM4 / CP4) |
| UniProt | P28720 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Queuine tRNA-ribosyltransferase |
| UniProt Accession | P28720 |
| Component Type | Protein |
| Sequence Length | 386 aa |
Queuine tRNA-ribosyltransferase
How to read this target
Review this target as Queuine tRNA-ribosyltransferase, mapped to UniProt P28720. Sequence length is 386 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL14926 | 7.0 | Ki | 100.0 | Preclinical |
| CHEMBL14913 | 6.6 | Ki | 250.0 | Preclinical |
| CHEMBL418720 | 6.52 | Ki | 300.0 | Preclinical |
| CHEMBL278009 | 6.22 | Ki | 600.0 | Preclinical |
| CHEMBL276808 | 5.57 | Ki | 2700.0 | Preclinical |
| CHEMBL277561 | 5.42 | Ki | 3800.0 | Preclinical |
| CHEMBL277134 | 5.33 | Ki | 4700.0 | Preclinical |
| CHEMBL278733 | 5.3 | Ki | 5000.0 | Preclinical |
| CHEMBL14996 | 5.09 | Ki | 8100.0 | Preclinical |
| CHEMBL14882 | 5.08 | Ki | 8300.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 1 assays, 17 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 17 | 5.4 |