Dihydroorotate dehydrogenase (quinone), mitochondrial · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt O35435. Use UniProt O35435 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O35435 as the stable identity anchor, then attach disease evidence before program review.
Dihydroorotate dehydrogenase (quinone), mitochondrial
Review this target as Dihydroorotate dehydrogenase (quinone), mitochondrial, mapped to UniProt O35435. Sequence length is 395 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydroorotate dehydrogenase (quinone), mitochondrial as ChEMBL target CHEMBL2991, mapped to UniProt O35435. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydroorotate dehydrogenase (quinone), mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | O35435 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydroorotate dehydrogenase (quinone), mitochondrial |
| UniProt Accession | O35435 |
| Component Type | Protein |
| Sequence Length | 395 aa |
Dihydroorotate dehydrogenase (quinone), mitochondrial
Review this target as Dihydroorotate dehydrogenase (quinone), mitochondrial, mapped to UniProt O35435. Sequence length is 395 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5193821 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL2111978 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL960 | 7.52 | IC50 | 30.0 | Approved |
| CHEMBL358411 | 7.44 | IC50 | 36.0 | Preclinical |
| CHEMBL143518 | 7.44 | IC50 | 36.0 | Preclinical |
| CHEMBL142214 | 7.44 | IC50 | 36.0 | Preclinical |
| CHEMBL143116 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL141195 | 7.38 | IC50 | 42.0 | Preclinical |
| CHEMBL141732 | 7.33 | IC50 | 47.0 | Preclinical |
| CHEMBL344556 | 7.3 | IC50 | 50.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 7 | 6.4 |
| assay format | 1 | 1 | 5.6 |
| cell-based format | 1 | 6 | 6.0 |
| organism-based format | 1 | 64 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 2 | 6.3 |
| single protein format | 1 | 0 | — |