Review anchor
Dihydroorotate dehydrogenase (quinone), mitochondrial
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
Evidence Snapshot
Dihydroorotate dehydrogenase (quinone), mitochondrial
CHEMBL2991
SINGLE PROTEIN
Mus musculus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydroorotate dehydrogenase (quinone), mitochondrial as ChEMBL target CHEMBL2991, mapped to UniProt O35435. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL2991
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O35435
Dihydroorotate dehydrogenase (quinone), mitochondrial
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Dihydroorotate dehydrogenase (quinone), mitochondrial matters
Dihydroorotate dehydrogenase (quinone), mitochondrial is reviewed as Dihydroorotate dehydrogenase (quinone), mitochondrial (UniProt O35435); the current evidence base includes 2 approved drugs, 100 compounds, and 7 assays, with lead potency reaching pChEMBL 8.0.
Protein context
Dihydroorotate dehydrogenase (quinone), mitochondrial
Dihydroorotate dehydrogenase (quinone), mitochondrial Sequence length is 395 aa.
Review this target as Dihydroorotate dehydrogenase (quinone), mitochondrial, mapped to UniProt O35435. Sequence length is 395 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt O35435
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 2 approved drugs, 100 compounds, and 7 assays for this target. The dominant activity type is IC50. CHEMBL5193821 is the current potency anchor at pChEMBL 8.0.
Use CHEMBL5193821 as the tractability anchor when discussing potency (pChEMBL 8.0).
Activity source · ChEMBL 36 via Core Engine
2 approved
pChEMBL 8.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Dihydroorotate dehydrogenase (quinone), mitochondrial matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt O35435, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
100
Total Compounds
7
Total Assays
2
Approved Drugs
IC50: 99.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL5193821
|
8.0 | IC50 | — |
|
|
No preferred name
CHEMBL2111978
|
7.7 | IC50 | — |
|
|
No preferred name
CHEMBL960
|
7.5 | IC50 | Approved |
|
|
No preferred name
CHEMBL358411
|
7.4 | IC50 | — |
|
|
No preferred name
CHEMBL143518
|
7.4 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
TERIFLUNOMIDE
CHEMBL973
|
2012 |
|
|
LEFLUNOMIDE
CHEMBL960
|
1998 |
Source Header