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Target Snapshot

CHEMBL3123 Target Snapshot

Death-associated protein kinase 2 · SINGLE PROTEIN · Homo sapiens

547Compounds
183Assays
5Approved Drugs
170.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q9UIK4. Use UniProt Q9UIK4 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UIK4 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Death-associated protein kinase 2 as ChEMBL target CHEMBL3123, mapped to UniProt Q9UIK4. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Death-associated protein kinase 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3123
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9UIK4
Death-associated protein kinase 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Death-associated protein kinase 2 is the right protein anchor across sources, using UniProt Q9UIK4 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDeath-associated protein kinase 2
UniProt AccessionQ9UIK4
Component TypeProtein
Sequence Length370 aa

Death-associated protein kinase 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Death-associated protein kinase 2, mapped to UniProt Q9UIK4. Sequence length is 370 aa.

Mapped IDQ9UIK4
Review nameDeath-associated protein kinase 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

5
Approved
2
Phase III
3
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC5024.0
KD146.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL388978 8.8 Kd 1.6 Preclinical
CHEMBL388978 8.28 IC50 5.21 Preclinical
CHEMBL3103192 8.0 IC50 10.0 Preclinical
CHEMBL4764610 7.66 IC50 22.0 Preclinical
CHEMBL1287853 7.54 Kd 29.0 Approved
CHEMBL4465866 7.47 Kd 34.0 Preclinical
CHEMBL4576489 7.22 Kd 60.0 Preclinical
CHEMBL475251 7.21 Kd 62.0 Clinical
CHEMBL603469 7.2 Kd 63.0 Clinical
CHEMBL5303531 7.1 Kd 79.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
12
5.5
17
6.0
4
6.5
8
7.0
2
7.5
4
8.0
3
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

FEDRATINIB
CHEMBL1287853
Approved 2019
MIDOSTAURIN
CHEMBL608533
Approved 2017
RUXOLITINIB
CHEMBL1789941
Approved 2011
SUNITINIB
CHEMBL535
Approved 2006
Assay Landscape

Assay Landscape

183
Total Assays
42
Tested Compounds
1
Assay Types
Binding — 183 assays, 42 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 153 38 6.5
assay format 19 0
cell-based format 11 4 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine