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Target Snapshot

CHEMBL3181 Target Snapshot

17-beta-hydroxysteroid dehydrogenase type 1 · SINGLE PROTEIN · Homo sapiens

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1,408Compounds
182Assays
2Approved Drugs
966.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P14061. Use UniProt P14061 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P14061 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 17-beta-hydroxysteroid dehydrogenase type 1 as ChEMBL target CHEMBL3181, mapped to UniProt P14061. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
17-beta-hydroxysteroid dehydrogenase type 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3181
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P14061
17-beta-hydroxysteroid dehydrogenase type 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 17-beta-hydroxysteroid dehydrogenase type 1 is the right protein anchor across sources, using UniProt P14061 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred Name17-beta-hydroxysteroid dehydrogenase type 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP14061
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label17-beta-hydroxysteroid dehydrogenase type 1
UniProt AccessionP14061
Component TypeProtein
Sequence Length328 aa

17-beta-hydroxysteroid dehydrogenase type 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as 17-beta-hydroxysteroid dehydrogenase type 1, mapped to UniProt P14061. Sequence length is 328 aa.

Mapped IDP14061
Review name17-beta-hydroxysteroid dehydrogenase type 1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50955.0
KI11.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4457145 10.0 IC50 0.1 Preclinical
CHEMBL4529443 10.0 IC50 0.1 Preclinical
CHEMBL4063985 9.7 IC50 0.2 Preclinical
CHEMBL4103524 9.52 IC50 0.3 Preclinical
CHEMBL4101264 9.4 IC50 0.4 Preclinical
CHEMBL4283851 9.4 IC50 0.4 Preclinical
CHEMBL4063839 9.3 IC50 0.5 Preclinical
CHEMBL4079675 9.3 IC50 0.5 Preclinical
CHEMBL4454887 9.3 IC50 0.5 Preclinical
CHEMBL4466918 9.22 IC50 0.6 Preclinical
Distribution

pChEMBL Value Distribution

88
5.0
63
5.5
104
6.0
118
6.5
123
7.0
105
7.5
65
8.0
39
8.5
13
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

ESTRONE
CHEMBL1405
Approved 1979
Properties Compare Identifier
Assay Landscape

Assay Landscape

182
Total Assays
698
Tested Compounds
2
Assay Types
Binding — 180 assays, 698 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 81 143 6.6
assay format 62 431 7.0
single protein format 33 92 5.4
subcellular format 3 23 7.3
tissue-based format 1 9 7.3
Functional — 2 assays, 15 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 15 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine