Review anchor
17-beta-hydroxysteroid dehydrogenase type 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
17-beta-hydroxysteroid dehydrogenase type 1
CHEMBL3181
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 17-beta-hydroxysteroid dehydrogenase type 1 as ChEMBL target CHEMBL3181, mapped to UniProt P14061. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL3181
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P14061
17-beta-hydroxysteroid dehydrogenase type 1
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why 17-beta-hydroxysteroid dehydrogenase type 1 matters
17-beta-hydroxysteroid dehydrogenase type 1 is reviewed as 17-beta-hydroxysteroid dehydrogenase type 1 (UniProt P14061); the current evidence base includes 2 approved drugs, 1408 compounds, and 182 assays, with lead potency reaching pChEMBL 10.0.
Protein context
17-beta-hydroxysteroid dehydrogenase type 1
17-beta-hydroxysteroid dehydrogenase type 1 Sequence length is 328 aa.
Review this target as 17-beta-hydroxysteroid dehydrogenase type 1, mapped to UniProt P14061. Sequence length is 328 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P14061
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 2 approved drugs, 1408 compounds, and 182 assays for this target. The dominant activity type is IC50. CHEMBL4457145 is the current potency anchor at pChEMBL 10.0.
Use CHEMBL4457145 as the tractability anchor when discussing potency (pChEMBL 10.0).
Activity source · ChEMBL 36 via Core Engine
2 approved
pChEMBL 10.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why 17-beta-hydroxysteroid dehydrogenase type 1 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P14061, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
1408
Total Compounds
182
Total Assays
2
Approved Drugs
IC50: 955.0, KI: 11.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL4457145
|
10.0 | IC50 | — |
|
|
No preferred name
CHEMBL4529443
|
10.0 | IC50 | — |
|
|
No preferred name
CHEMBL4063985
|
9.7 | IC50 | — |
|
|
No preferred name
CHEMBL4103524
|
9.5 | IC50 | — |
|
|
No preferred name
CHEMBL4101264
|
9.4 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
ESTRONE
CHEMBL1405
|
1979 |
Source Header