CD44 antigen · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14CD44 antigen shows clinical signal disease relevance led by breast neoplasm. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P16070. Start with breast neoplasm, then reuse UniProt P16070 as the stable protein anchor across project notes and exports.
Start with breast neoplasm, then reuse UniProt P16070 as the stable protein anchor across project notes and exports.
CD44 antigen shows clinical signal disease relevance led by breast neoplasm. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with breast neoplasm because it currently carries clinical signal support. Linked drugs include BIVATUZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCD44 antigen
Review this target as CD44 antigen, mapped to UniProt P16070. Sequence length is 742 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats CD44 antigen as ChEMBL target CHEMBL3232692, mapped to UniProt P16070. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether CD44 antigen is the right protein anchor across sources, using UniProt P16070 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why breast neoplasm is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | CD44 antigen |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P16070 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | CD44 antigen |
| UniProt Accession | P16070 |
| Component Type | Protein |
| Sequence Length | 742 aa |
CD44 antigen
Review this target as CD44 antigen, mapped to UniProt P16070. Sequence length is 742 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
CD44 antigen shows clinical signal disease relevance led by breast neoplasm. 2 more disease programs remain visible in the same review block.
Start review with breast neoplasm because it currently carries clinical signal support. Linked drugs include BIVATUZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3237623 | 5.47 | Kd | 3400.0 | Preclinical |
| CHEMBL3237622 | 4.94 | Kd | 11500.0 | Preclinical |
| CHEMBL3237621 | 4.78 | Kd | 16700.0 | Preclinical |
| CHEMBL5629990 | 4.62 | IC50 | 24000.0 | Preclinical |
| CHEMBL3237623 | 4.44 | IC50 | 36000.0 | Preclinical |
| CHEMBL3237620 | 4.41 | Kd | 38800.0 | Preclinical |
| CHEMBL3237622 | 4.32 | IC50 | 48000.0 | Preclinical |
| CHEMBL3237621 | 4.19 | IC50 | 65000.0 | Preclinical |
| CHEMBL3237627 | 3.4 | Kd | 400000.0 | Preclinical |
| CHEMBL3237624 | 3.05 | Kd | 900000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 1 | 4.6 |
| single protein format | 3 | 11 | 3.5 |