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Evidence Snapshot

Amine oxidase [flavin-containing] A

CHEMBL3254 SINGLE PROTEIN Bos taurus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:42Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3254
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Amine oxidase [flavin-containing] A as ChEMBL target CHEMBL3254, mapped to UniProt P21398. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Amine oxidase [flavin-containing] A
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL3254
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P21398
Amine oxidase [flavin-containing] A
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Amine oxidase [flavin-containing] A matters

As of 2026-09-14

Amine oxidase [flavin-containing] A is reviewed as Amine oxidase [flavin-containing] A (UniProt P21398); the current evidence base includes 7 approved drugs, 446 compounds, and 24 assays, with lead potency reaching pChEMBL 11.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 7 approved drugs, 446 compounds, and 24 assays for this target. The dominant activity type is KI. CHEMBL2178425 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL2178425 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
7 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Amine oxidase [flavin-containing] A matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P21398, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

446
Total Compounds
24
Total Assays
7
Approved Drugs
IC50: 125.0, KI: 213.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL2178425
 11.0 Ki —
No preferred name
CHEMBL2178984
 11.0 Ki —
No preferred name
CHEMBL2178990
 11.0 Ki —
No preferred name
CHEMBL2178986
 10.9 Ki —
No preferred name
CHEMBL2178988
 10.9 Ki —

Approved Drugs

Structure Compound First Approval
TACRINE
CHEMBL95
 1993
TOLOXATONE
CHEMBL18116
 1984
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:42Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3254